During the process of E. coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products. The availability of highly purified proteins has lead to a detailed molecular description of E. coli nucleotide excision repair that serves as a model for similar processes in eukaryotes. An interesting aspect of this repair system is the protein complex's ability to work on a vast array of DNA lesions that differ widely in (...) their chemical composition and molecular architecture. Here we propose a model for damage recognition in which the UvrB protein serves as the component that confers enhanced specificity to a preincision complex. We hypothesize that one major determinant for the formation of a stable preincision complex appears to be the disruption of base stacking interactions by DNA lesions. (shrink)

We highlight a recent study exploring the hand‐off of UV damage to several key nucleotide excision repair (NER) proteins in the cascade: UV‐DDB, XPC and TFIIH. The delicate dance of DNA repair proteins is choreographed by the dynamic hand‐off of DNA damage from one recognition complex to another damage verification protein or set of proteins. These DNA transactions on chromatin are strictly chaperoned by post‐translational modifications (PTM). This new study examines the role that ubiquitylation and subsequent DDB2 degradation has during (...) this process. In total, this study suggests an intricate cellular timer mechanism that under normal conditions DDB2 helps recruit and ubiquitylate XPC, stabilizing XPC at damaged sites. If DDB2 persists at damaged sites too long, it is turned over by auto‐ubiquitylation and removed from DNA by the action of VCP/p97 for degradation in the 26S proteosome. (shrink)

Packed with ideas designed to help children learn to sing, this booklet offers criteria for selecting songs, strategies to bring out the best in children's voices, and suggestions for games, ideas, and resources.

The Bewys van den waren Godsdienst and De veritate religionis Christianae originated against the background of Grotius’s familiarity with classical literature. To understand the innovative impact of these writings, the historical method applied must be considered. Grotius did not rely on authorities, but was compiling historical witnesses for the three religions. The availability and visibility of the witness reports are regularly referred to in the text. Thus, history and classical historians enter the picture. Interestingly, this cannot be separated from the (...) debate about the methods to be used in geography, a matter that gains importance as the difference between Bewys and De veritate is nowhere as visible as in the geographical references. The generous sprinkling of place names from different continents contributes to the poem’s factual character. The place names in the Bewys derive from the Dutch sea trade and can be found in the travel reports of the time. This is elucidated by two examples: the island Waygat in the Artic, and the coast of Mina in the Gulf of Guinea. In De veritate, however, all such references are removed. In their stead appear examples from ancient topography, to be annotated in the 1640 edition with ample quotations from Pliny, Strabo, Josephus and others. (shrink)

Gedurende 2017 herdenk Lutherse en Calvinistiese kerke die Kerkhervorming wat 500 jaar gelede plaasgevind het. Hierdie hoofstuk fokus op Johannes Calvyn se eerste publikasies, dit wil sê publikasies wat verskyn het voordat hy met sy bediening in Genève begin het. Die fokus val op die drie belangrikste publikasies in hierdie periode, te wete sy 'Kommentaar op Seneca se De Clementia', die 'De Psychopannychia' en die eerste uitgawe van sy 'Christianae Religionis Institutio'. In hierdie eerste drie publikasies is 'n jeugdige Calvyn (...) aan die woord. Ten spyte daarvan is die publikasies omvangryk en is dit duidelik dat Calvyn vroeg in sy lewe oor omvangryke kennis en insig beskik het. Die vroegste publikasies word somtyds as van minder belang geag. In hierdie bydrae word die stelling gemaak dat die publikasies van groot belang is omdat Calvyn talle van die gedagtes wat later in sy werke na vore kom, reeds in sy vroeë werke aan die orde gestel het. (shrink)

These notes contain an annotated edition of the only four extant letters of Burchard de Volder to Philipp van Limborch. In the first letter De Volder provides Van Limborch with some information about the subscription to the Dordrecht Confession of Faith by professors. In the second letter De Volder comments upon Van Limborch’s De veritate religionis Christianae. This letter is interesting as it provides insights into De Volder’s views on religion and theology. The third letter served as a cover letter (...) for De Volder’s sending to Van Limborch a copy of the honestum testimonium on Jacobus Arminius that was requested by Arminius’s widow in 1611. In the fourth letter Volder comments upon the visit that Pieter Burman had paid him. The visit was an episode in the quarrel between Pieter Burman, his brother Frans Burman jr., and Van Limborch, caused by Van Limborch’s remark, in his Theologia Christiana, that Frans Burman sr. had used Spinoza’s words while treating the issue of divine omnipotence in his Synopsis theologiae. (shrink)

Botha, PJ - Deist, FE Le Roux, JH 1987. Revolution and reinterpretation: Chapters from the history of Israel. (Bladsy 201)Geyser, PA - De Villiers, PGR 1987. Liberation theology and the Bible. (Bladsy 203)Naudé, RM - Kriel, JR 1988. Removing medicine’s cartesian mask: The problem of humanising medical education. (Bladsy 206)Stander, HF - Ferguson, E 1987. Backgrounds of early Christianity. (Bladsy 207)Stander, HF - Durst, M 1987. Die Eschatologie des Hilarius von Poitiers: Ein Beitrag zur Dogmengeschichte des vierten Jahrliunderts. (Bladsy 209)Storm, (...) JMG - Loubser, JA 1987. The apartheid Bible. A critical review of racial theology in South Africa. (Bladsy 212)Van der Merwe, PJ - Krüger, JS 1988. Aandag, kalmte en insig. (Bladsy 215)Van der Merwe, JC - Van der Walt, BJ 1988. My roeping as Christenjongmens in die huidige Suid-Afrika. (Bladsy 217)Van der Westhuizen, HG - Van Houten, RL 1988. The Message of Harare. (Bladsy 222)Van der Westhuizen, HG - Du Preez, J 1988. Die aantrekkingskrag van die Marxisme vir die Derde Wereld. (Bladsy 225)Van Staden, AJ - Algemene Kommissie vir die Diens van Barmhartigheid van die Nederduitse Gereformeerde Kerk 1986. Die diakonaat en die alkohol- en dwelmaflianklike. (Bladsy 227). (shrink)

Trust and corporation (extracts) / by F.W. Maitland -- Respublica Christiana -- by J.N. Figgis -- Society and state / by R.M. MacIver -- The discredited state / by E. Barker -- Conflicting social obligations / by G.D.H. Cole -- Community is a process / by M.P. Follett -- The eruption of the group / by E. Barker -- The masses in a representative democracy / by M. Oakeshott -- The atavism of social justice / by F.A. von Hayek (...) -- Collective entities and moral rights / by V. van Dyke -- Capitalism, citizenship and community / by S. Macedo -- Liberalism and the politicization of ethnicity / by W. Kymlicka -- Are there any cultural rights? / by C. Kukathas -- The civil society argument / by M. Walzer. (shrink)

Celem autora było udowodnienie, że kalwaria Mikołaja Zebrzydowskiego nie była (jak dotychczas twierdzono) wzniesiona na terenie pustostanu. Skopiowana na ziemiach pomiędzy Górą Żar a Górą Lanckorońską za traktatem Christiana Kruik van Adrichema Jerozolima obejmowała przede wszystkim królewszczyzny, głównie wsie Zakrzów, Stronie i Leśnicę. Nałożenie układu Miasta Świętego na tereny wiejskie spowodowało zabranie chłopom najbardziej urodzajnych pól znajdujących się na południowych stokach, a w konsekwencji m.in. głód i migrację. W związku z tym autor rozpatrzył fundację kompleksu jako powód zmian układów (...) ruralistycznych i przemieszczeń ludności chłopskiej. W tym celu zostały przeanalizowane odpisy z nieistniejących ksiąg kancelarii kościelnych, rzucające nowe światło na fundację polskiej Jerozolimy. Zawarte w nich wiadomości, uzupełnione informacjami ze źródeł Archiwum Głównego Akt Dawnych w Warszawie, Archiwum Kurii Metropolitalnej i Archiwum Prowincji Bernardynów w Krakowie oraz z wydanymi drukiem materiałami dały spójny obraz sytuacji tenuty zakrzowskiej w XVII wieku. Już w pierwszej połowie tego stulecia nastąpił niemal całkowity upadek wsi Leśnica i zmiany organizacji wsi Stronie, którą końcem XVII wieku starano się ratować zakładaniem nowego osiedla na wzgórzu Niespiennik. Na pozostałych w rękach chłopów kamienistych polach, położonych na północnych stokach, rósł tylko owies. Poza tym spustoszenie przynosiły wylewy rzeki Stryszówki. Zaprowadzona przez Zebrzydowskiego fundacja odcisnęła się także na wiejskiej parafii Stryszów, której proboszcz zaczął od początku XVII stulecia notować spadek liczby przychodzących do stryszowskiego kościoła parafian i wydawanego mu z obu wsi mesznego. (shrink)

This is the first extensive study of ecological virtue ethics and the new rhetoric of environmentalists. Based on a wide-ranging survey of environmental literature, Louke van Wensveen offers an overview of current "green" virtue language and proposes the basic elements of a matching ecological virtue theory, dubbed "dirty virtues" by ecological philosophers.Environmental ethics is not exhausted by debates about the need to preserve rivers, our duties to bioregions, and the intrinsic value of nonhuman nature; rather, ecoliterature also contains a rich (...) virtue language. Highlighting the integrity, diversity, internal tensions, dynamism, and visionary character of this ecological virtue language, the author shows both its historical roots and innovative features. Van Wensveen illustrates a widespread awareness of attitudes and habits that help or harm our relations with the nonhuman world. She includes a unique catalog of 189 virtues and 174 vices that mark the vision and praxis of people committed to ecological flourishing.The second part of Dirty Virtues presents carefully crafted criteria to help discern genuine virtue and vice in an ecological age. Her arguments are distinguished by a critical balance of moral sources, including Aristotelian virtue theory, Christian tradition, women's experiences, psychological theory, and metaphorical representations of nonhuman nature.Methodologically innovative and boldly interdisciplinary, Dirty Virtues will challenge and inspire virtue theorists, as well as environmental ethicists and theologians. (shrink)

Objective: Illness perceptions are important predictors of emotional and behavioral responses in many diseases. The current study aims to investigate the COVID-19-related IP throughout Europe. The specific goals are to understand the temporal development, identify predictors and examine the impacts of IP on perceived stress and preventive behaviors.Methods: This was a time-series-cross-section study of 7,032 participants from 16 European countries using multilevel modeling from April to June 2020. IP were measured with the Brief Illness Perception Questionnaire. Temporal patterns were observed (...) considering the date of participation and the date recoded to account the epidemiological evolution of each country. The outcomes considered were perceived stress and COVID-19 preventive behaviors.Results: There were significant trends, over time, for several IP, suggesting a small decrease in negativity in the perception of COVID-19 in the community. Age, gender, and education level related to some, but not all, IP. Considering the self-regulation model, perceptions consistently predicted general stress and were less consistently related to preventive behaviors. Country showed no effect in the predictive model, suggesting that national differences may have little relevance for IP, in this context.Conclusion: The present study provides a comprehensive picture of COVID-19 IP in Europe in an early stage of the pandemic. The results shed light on the process of IP formation with implications for health-related outcomes and their evolution. (shrink)

Sound and complete axiomatizations are provided for a number of different logics involving modalities for the knowledge of multiple agents and operators for branching time, extending previous work of Halpern, van der Meyden and Vardi [to appear, SIAM Journal on Computing] for logics of knowledge and linear time. The paper considers the system constraints of synchrony, perfect recall and unique initial states, which give rise to interaction axioms. The language is based on the temporal logic CTL*, interpreted with respect to (...) a version of the bundle semantics. (shrink)

Background Notwithstanding the need to produce evidence-based knowledge on medications for pregnant women, they remain underrepresented in clinical research. Sometimes they are excluded because of their supposed vulnerability, but there are no universally accepted criteria for considering pregnant women as vulnerable. Our aim was to explore whether and if so to what extent pregnant women are vulnerable as research subjects. Method We performed a conceptual and empirical analysis of vulnerability applied to pregnant women. Analysis A conceptual analysis supports Hurst's definition (...) of vulnerability. Consequently, we argue that pregnant women are vulnerable if they encounter an identifiably increased likelihood of incurring additional or greater wrong. According to the literature, this increased likelihood could exist of four alleged features for pregnant women's vulnerability: informed consent, susceptibility to coercion, higher exposure to risk due to lack of knowledge, vulnerability of the fetus. Discussion Testing the features against Hurst's definition demonstrates that they all concern the same issue: pregnant women are only vulnerable because a higher exposure to risk due to lack of scientific knowledge comprises an increased wrong. Research Ethics Committees have a responsibility to protect the vulnerable, but a higher exposure to risk due to lack of scientific knowledge is a much broader issue and also needs to be addressed by other stakeholders. Conclusions The only reason why pregnant women are potentially vulnerable is to the extent that they are increasingly exposed to higher risks due to a lack of scientific knowledge. Accordingly, the discussion can advance to the development of practical strategies to promote fair inclusion of pregnant women in clinical research. (shrink)

This article provides an affirmative feminist reading of the philosophy of Henri Bergson by reading it through the work of Karen Barad. Adopting such a diffractive reading strategy enables feminist philosophy to move beyond discarding Bergson for his apparent phallocentrism. Feminist philosophy finds itself double bound when it critiques a philosophy for being phallocentric, because the setup of a master narrative comes into being with the critique. By negating a gender-blind or sexist philosophy, feminist philosophy only reaffirms its parameters, and (...) setting up a master narrative costs feminist philosophy its feminism. I thus propose and practice a different methodological starting point, one that capitalizes on “diffraction.” This article experiments with the affirmative phase in feminist philosophy prophesied by Elizabeth Grosz, among others. Working along the lines of the diffractive method, the article at the same time proposes a new reading of Bergson (as well as of Barad), a new, different metaphysics indeed, which can be specified as onto-epistemological or “new materialist.”. (shrink)

In dit artikel wordt de dominante metafysische oriëntatie in de hedendaagse meta-ethiek kritisch onder de loep genomen. Het hedendaagse debat, dat zich voornamelijk richt op de vraag hoe moraliteit metafysisch gezien 'in de werkelijkheid past', wordt gekenmerkt door een reeks complexe en soms esoterische discussies die, zo wordt betoogd, weinig bijdragen aan ons filosofische begrip van ethiek. Deze focus op metafysische grondslagen heeft geleid tot een tunnelvisie, waarin het debat gevangen zit tussen steeds ingewikkeldere vormen van non-cognitivisme, herconceptualisaties van 'objectiviteit' (...) en metafysische acrobatiek. Als alternatief wordt voorgesteld de aandacht in de meta-ethiek te verleggen naar het domein van praktisch redeneren. Door ons te concentreren op de patronen van geldige praktische argumentatie en het soort overwegingen dat mensen daadwerkelijk overtuigt, kunnen we wellicht een beter inzicht krijgen in de aard van ethische normativiteit en de rol ervan in ons leven. Het artikel pleit voor een meer pragmatische en minder metafysisch beladen benadering van de meta-ethiek, die zich richt op de daadwerkelijke praktijken van moreel redeneren en argumenteren. (shrink)

Ludwig Feuerbach is traditionally regarded as a significant but transitional figure in the development of nineteenth-century German thought. Readings of Feuerbach's The Essence of Christianity tend to focus on those features which made it seem liberating to the Young Hegelians: namely, its criticism of reification as abstraction, and its interpretation of religion as alienation. In this book, Van Harvey claims that this is a limited and inadequate view of Feuerbach's work, especially of his critique of religion. The author argues that (...) Feuerbach's philosophical development led him to a much more complex and interesting theory of religion which he expounded in works which have been virtually ignored hitherto. By exploring these works, Harvey gives them a significant contemporary re-statement, and brings Feuerbach into conversation with a number of modern theorists of religion. (shrink)

Certain organoid subtypes are particularly sensitive. We explore whether moral intuitions about the heartbeat warrant unique moral consideration for newly advanced contracting cardiac organoids. Despite the heartbeat’s moral significance in organ procurement and abortion discussions, we argue that this significance should not translate into moral implications for cardiac organoids.

Information is a recognized fundamental notion across the sciences and humanities, which is crucial to understanding physical computation, communication, and human cognition. The Philosophy of Information brings together the most important perspectives on information. It includes major technical approaches, while also setting out the historical backgrounds of information as well as its contemporary role in many academic fields. Also, special unifying topics are high-lighted that play across many fields, while we also aim at identifying relevant themes for philosophical reflection. There (...) is no established area yet of Philosophy of Information, and this Handbook can help shape one, making sure it is well grounded in scientific expertise. As a side benefit, a book like this can facilitate contacts and collaboration among diverse academic milieus sharing a common interest in information. . First overview of the formal and technical issues involved in the philosophy of information . Integrated presentation of major mathematical approaches to information, form computer science, information theory, and logic . Interdisciplinary themes across the traditional boundaries of natural sciences, social sciences, and humanities. (shrink)

Objective—Consultation of another physician is an important method of review of the practice of euthanasia. For the project “support and consultation in euthanasia in Amsterdam” which is aimed at professionalising consultation, a protocol for consultation was developed to support the general practitioners who were going to work as consultants and to ensure uniformity. Participants—Ten experts (including general practitioners who were experienced in euthanasia and consultation, a psychiatrist, a social geriatrician, a professor in health law and a public prosecutor) and the (...) general practitioners who were going to use the protocol. Evidence—There is limited literature on consultation: discursive articles and empirical studies describing the practice of euthanasia. Consensus—An initial draft on the basis of the literature was commented on by the experts and general practitioners in two rounds. Finally, the protocol was amended after it had been used during the training of consultants. Conclusions—The protocol differentiates between steps that are necessary in a consultation and steps that are recommended. Guidelines about four important aspects of consultation were given: independence, expertise, tasks and judgment of the consultant. In 97% of 109 consultations in which the protocol was used the consultant considered the protocol to be useful to a greater or lesser extent. Although this protocol was developed locally, it also employs universal principles. Therefore it can be of use in the development of consultation elsewhere. (shrink)

Fabi and Goldberg have helpfully shed some light on the wrongs perpetuated by the current funding architecture on research, sponsorship, and career development in the field of bioethics. The...

The technological advances in medicine, including prolongation of life, have constituted several dilemmas at the end of life. In the context of the Belgian debates on end-of-life care, the views of Muslim women remain understudied. The aim of this article is fourfold. First, we seek to describe the beliefs and attitudes of middle-aged and elderly Moroccan Muslim women toward withholding and withdrawing life-sustaining treatments. Second, we aim to identify whether differences are observable among middle-aged and elderly women’s attitudes toward withholding (...) and withdrawing life-sustaining treatments. Third, we aim to explore the role of religion in their attitudes. Fourth, we seek to document how our results are related to normative Islamic literature. Qualitative empirical research was conducted with a sample of middle-aged and elderly Moroccan Muslim women living in Antwerp and with experts in the field. We found an unconditional belief in God’s sovereign power over the domain of life and death and in God’s almightiness. However, we also found a tolerant attitude, mainly among our middle-aged participants, toward withholding and withdrawing based on theological, eschatological, financial and quality of life arguments. Our study reveals that religious beliefs and worldviews have a great impact on the ethical attitudes toward end-of-life issues. We found divergent positions toward withholding and withdrawing life-sustaining treatments, reflecting the lines of reasoning found in normative Islamic literature. In our interviews, theological and eschatological notions emerged as well as financial and quality of life arguments. (shrink)

One of the reasons why empathy is a topic of enduring interest is the role it can play in understanding others. Empathy can help us to predict each other’s future actions and explain past ones; to...

Academic dishonesty (AD) is a threat to quality education, ethics of professional practices and career outcomes. Psychopathy is connected to AD. This study investigated whether academic confidence (AC) mediates the relationship between psychopathy and AD. University students (N = 335, mean age = 18.38 years) completed measures of relevant variables, in addition to providing demographic details. Results of statistical analysis showed that AC mediated the association between primary psychopathy and AD. Considering the extent of students' belief, trust and expectation that (...) they can execute their academic tasks by themselves could be important target in enhancing ethical behaviors among students. (shrink)